Methotrexate (MTX) is used widely at a low-dose for its antirheumatic and anti-inflammatory benefits. Unfortunately, MTX also depletes the body's folates, an essential class of vitamins, which may lead to MTX induced side-effects. Folic acid is recommended for patients taking MTX to replenish their body's folates and help prevent side-effects.
Research has shown that patients taking folic acid with MTX experience fewer side-effects and are able to take MTX for longer periods. However, despite taking folic acid, some patients continue to suffer from MTX induced side effects.
Unfortunately, your body can't use folic acid unless it's converted by the body to a bio-active form. To make matters worse, this conversion is inhibited by MTX. This may account for MTX induced side effects in patients who are also taking folic acid. Rheumate provides L-methylfolate, a naturally occurring bio-active folate abundant in green leafy vegetables. L-methylfolate is "ready-to-go" and unlike folic acid, can replenish the body's folates without conversion. Rheumate provides L-methylfolate because it's what the body needs to replenish your body's folates that have been depleted by MTX.
Rheumate offers significant advantages over folic acid for patients who are concerned about MTX toxicity.