• Manages Multiple MTX
    Induced Side Effects

    Rheumate delivers L-methylfolate because it has significantly greater bio-activity compared to folic acid and avoids any issues resulting from common SNPs that interfere with the body's ability to use folates.

  • Folate Metabolism
    in the Body

    L-methylfolate restores folates, curcumin supports healthy methotrexate liver metabolism, and vitamin B-12 provides an added safeguard.

Manages Multiple MTX Induced Side Effects


Methotrexate (MTX) is used widely at a low-dose for its antirheumatic and anti-inflammatory benefits. Unfortunately, MTX also depletes the body's folates, an essential class of vitamins, which may lead to MTX induced side-effects. Folic acid is recommended for patients taking MTX to replenish their body's folates and help prevent side-effects.

Research has shown that patients taking folic acid with MTX experience fewer side-effects and are able to take MTX for longer periods. However, despite taking folic acid, some patients continue to suffer from MTX induced side effects.

Unfortunately, your body can't use folic acid unless it's converted by the body to a bio-active form. To make matters worse, this conversion is inhibited by MTX. This may account for MTX induced side effects in patients who are also taking folic acid. Rheumate provides L-methylfolate, a naturally occurring bio-active folate abundant in green leafy vegetables. L-methylfolate is "ready-to-go" and unlike folic acid, can replenish the body's folates without conversion. Rheumate provides L-methylfolate because it's what the body needs to replenish your body's folates that have been depleted by MTX.

Rheumate offers significant advantages over folic acid for patients who are concerned about MTX toxicity.

  • Why Rheumate?
  • Why Medical Foods?
Why Rheumate?
RHEUMATE is a specially formulated prescription medical food product for the clinical dietary management of metabolic effects of methotrexate therapy administered to patients with chronic inflammatory diseases.
Why Medical Foods?
Medical foods are an official Food and Drug Administration (FDA) category of products that must have therapeutic value based on recognized science. The name “medical foods” was chosen by the FDA. All medical foods must meet the distinctive dietary requirements of a particular disease.