At Last, You Can Get the Folate Your Body Needs to Manage Methotrexate (MTX) Side Effects

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For the Clinical Dietary Management of the Metabolic Effects
of Methotrexate (MTX) Therapy for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that causes the body’s immune system to mistakenly attack the joints, resulting in inflammation of the joint lining. This inflammation of the joint lining (called the synovium) can cause pain, stiffness, swelling and redness in and around the joints, especially in the hands and feet. If left untreated, it can cause damage to cartilage and bones resulting in loss of normal movement and joint deformity, which can negatively impact quality of life. Because RA occurs throughout the body, other organs such as the skin, heart, lungs, and eyes may also be affected.

While there are many treatment options for patients living with Rheumatoid Arthritis (RA), the most common is methotrexate (MTX), which is classified as a DMARD (Disease-Modifying Anti-Rheumatic Drug). MTX is an effective anti-inflammatory, but it can deplete the body’s much needed supply of folate, an essential class of vitamins, which may lead to MTX-induced side effects.


When the body is unable to process folic acid and remains folate-deficient, the following symptoms may occur:

  • Nausea
  • Fatigue
  • Flu-Like Symptoms
  • Stomach Pain
  • Mouth Sores
  • Hair Loss
  • Elevated Liver Enzyme Levels
  • Low Number of Blood Cells (Leukopenia and Anemia)


Rheumate is the perfect companion to help reduce MTX-induced side-effects because it contains the bioactive folate the body needs.

Key Ingredients in Rheumate

High-quality, bioactive folate superior to folic acid because the body doesn't need to convert it.

Contains methylcobalamin, the most bioavailable form of B12 to avoid masking borderline B12 insufficiency with folate therapy.

Protects against MTX-induced liver damage, and has strong antioxidant properties (with an average ORAC of 13,500). The curcumin in Rheumate is 7x more bioavailable than ordinary curcumin.




*Rheumate is dispensed by prescription and is to be used under a physician's supervision.

How to Take Rheumate

The recommended dose of Rheumate is one or two capsules daily for the dietary management of the metabolic effects of methotrexate (MTX) therapy for rheumatoid arthritis or as directed by a physician.

All ingredients in Rheumate are categorized as GRAS (Generally Recognized As Safe) by the FDA.

Click to Get Information Tailored to Your Needs

Primus Care Direct is a hassle-free, mail-order pharmacy service where patients can get their Rheumate prescription for $35 for a 30-day supply or $87 for a 90-day supply ($29 per month), Medicare patients included. This is the lowest possible price available and includes free home delivery. If you have insurance, you may pay even less.

In addition to patient savings and convenience, Primus Care Direct saves time for healthcare practitioners by helping to increase fill rates and eliminating call-backs for prior authorizations.

Rheumate is also available at retail pharmacies, but Primus Care Direct guarantees patients will pay the lowest possible price on their prescription.

*Offer based on 30-day supply at prescribed one capsule per day dose

Advocating for Better Access to Rheumate

Without affordable access to Rheumate, and other prescription medical foods, patients will suffer. This is why Primus Pharmaceuticals (makers of Rheumate) started an advocacy movement to help patients, families, caregivers, healthcare providers and others have a voice to take control of their health with better access to safer medicines.

Increasingly, Medicare, Medicaid, Tricare and commercial health plans will only cover expensive synthetic drugs that merely treat symptoms and can cause serious adverse events.

Due to their safety profile and lack of drug-on-drug interaction, medical foods are often prescribed for chronic conditions in patient populations that have other diseases increasing their health risks from side effects associated with traditional drugs. Without easy access to prescription medical foods, patients in special co-morbid populations will continue to suffer.